Journal article
Hepatitis B Virus Flares after Nucleot(s)ide Analogue Cessation Are Associated with Activation of Toll-Like Receptor Signaling Pathways
SAL Hall, GS Burns, BJ Mooney, R Millen, R Morris, S Vogrin, V Sundararajan, D Ratnam, MT Levy, JS Lubel, AJ Nicoll, SI Strasser, W Sievert, PV Desmond, MC Ngu, P Angus, M Sinclair, C Meredith, G Matthews, PA Revill Show all
Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2023
Abstract
Background. We evaluated the patterns of peripheral Toll-like receptor (TLR) signaling activity and the expression of TLRs and natural killer (NK) cell activation in a cohort of patients experiencing severe hepatitis flares after stopping nucleot(s)ide analogues (NAs) therapy. Methods. Samples were collected longitudinally from patients with chronic hepatitis B who were enrolled in a prospective study of NA discontinuation. Patients experiencing hepatitis flares were compared with patients with normal alanine aminotransferase. Peripheral blood mononuclear cells (PBMCs) were stimulated with TLR ligands and cytokine secretion in the cell culture supernatant measured. Expression of TLR2/4, NKG2..
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Awarded by Gilead Sciences
Funding Acknowledgements
This work was funded by National Health and Medical Research Council of Australia Project Grant 1066536; A. J. T. received funding from the National Health and Medical Research Council of Australia (Medical Research Future Fund Practitioner Fellowship 1142976).